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The Black Death, caused by the bacterium Yersinia pestis, wiped out 30 to 50 percent of Europe’s population between 1347 and 1351. But, this is just the most infamous of the little microbe’s shenanigans. Y. pestis, which is one-millionth our size, has caused three major pandemics and continues killing people to this very day. The plague gets such a bad rap because it represents some of the greatest tragedies to ever befall the human race.